WebApr 3, 2024 · A transcription factor usually has one or more DNA-binding domains, and therefore can regulate the expression of multiple genes. Conversely, one gene can be regulated by many transcription factors. ... SCIRR69 is located in the cytoplasm of primary neurons under normal conditions, but it is transferred to the nucleus via shedding from …
The Cytoplasmic Factor in Plant Speciation - BioOne Complete
WebLINE-1 ORF-1p increased PXR transcription factor activity by enhancing the cytoplasmic/nuclear translocation of PXR and the recruitment of PXR to the CYP3A4 promoter or enhancer region. LINE-1 ORF-1p may also promote the clearance of sorafenib in HCC cells. Therefore, we conclude that LINE-1 ORF-1p could be a therapeutic target … Webthe extracellular domain of TF. The function of the cytoplasmic domain of TF is less clear. Its potential involvement in cell signaling is suggested by the presence of two serine residues that can be phosphorylated [13]. The cytoplasmic domain of TF is required for Factor VIIa-induced cellular responses such as generalised research
Characterization of mpl cytoplasmic domain sequences required …
WebAnalysis of their oncogenic potential in vivo indicated that a critical 69-amino-acid-long cytoplasmic domain of v-Mpl is required for myoproliferative leukemia virus pathogenicity. We also developed an in vitro assay and showed that expression of the env-mpl gene confers growth factor independence to murine as well as to human hematopoietic ... WebMar 21, 2005 · We found cytoplasmic HuR immunoreactivity in 40% of the 133 invasive ductal breast cancer specimens, and 29% of these samples showed high level of expression. This is in line with our previous data on serous ovarian carcinoma, in which we found cytoplasmic HuR expression in 52% of the cases (8). WebJul 14, 2024 · Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition to activating PARs, TF:FVIIa complex can also … generalised spatial modulation