Otub1 noncanonical
WebAug 19, 2010 · OTUB1 inhibits K48-linked ubiquitination of HIF-1α via its non-canonical inhibition of ubiquitination activity OTUB1 was previously identified as a member of the ovarian tumor domain containing... WebJan 1, 2024 · Otubain-1 (OTUB1) protease is identified as a novel amplifier of the proto-oncogene c-MYC, a critical cancer driver that correlates with inferior clinical outcomes in …
Otub1 noncanonical
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WebAug 1, 2010 · Here we report that OTUB1, a deubiquitinating enzyme, is an inhibitor of DSB-induced chromatin ubiquitination. Surprisingly, we found that OTUB1 suppresses … WebMay 13, 2024 · Thus, the hyper-production of IL-6 in Otub1-BKO mice was in line with the aberrant activation of canonical and noncanonical NF-κB in Otub1-deficient B cells. …
WebJan 1, 2024 · A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer-associated signaling pathways including MAPK, ERa, epithelial … WebApr 14, 2024 · 56.Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform. ... 257.Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to …
WebJan 1, 2024 · The non-canonical activity of OTUB1 was discovered by the Durocher laboratory in 2010, when they identified OTUB1 as a DUB that suppresses K63 chromatin ubiquitination in response to DNA damage ( Nakada et al. 2010 ). This observed K63-directed activity conflicted with previous reports that OTUB1 DUB activity is specific for … WebApr 1, 2024 · Given that OTUB1 possesses deubiquitinase activity and noncanonical function activity, PTMs in affecting OTUB1 function at these two aspects have been identified ( 27 ). Factor inhibiting HIF regulates OTUB1 deubiquitinase activity by catalyzing OTUB1 hydroxylation in an oxygen-dependent manner ( 29, 30 ).
WebAug 19, 2010 · OTUB1 functions as regulator of K63Ub (K63-linked polyubiquitin) synthesis in a noncanonical manner [9]. And K63Ub chain synthesis by ubiquitin-conjugating …
WebAug 1, 2010 · OTUB1 does so by binding to and inhibiting UBC13 (also known as UBE2N), the cognate E2 enzyme for RNF168. This unusual mode of regulation is unlikely to be limited to UBC13 because analysis of OTUB1-associated proteins revealed that OTUB1 binds to E2s of the UBE2D and UBE2E subfamilies. hop on the spotWebOTUB1 possesses a non-canonical, catalytic-independent activity where it inhibits the transfer of ubiquitin onto protein substrates by binding to the ubiquitin-charged E2. This review will describe the canonical and non-canonical activities of OTUB1, summarize OTUB1’s regulation of cancer-associated pathways and discuss OTUB1’s potential hop on the magic school busWebJan 27, 2015 · OTUB1 mediates prostate cancer cell invasion through RhoA activation and promotes tumorigenesis in vivo. Our results suggest that drugs targeting the catalytic activity of OTUB1 could potentially be used as therapeutics for … longwood gardens accessibilityWebJun 22, 2024 · OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation Cell Death Dis. 2024 Jun 22;13 (6):560. … longwood gardens 4th of julyWebJan 1, 2024 · Otubain-1 (OTUB1) protease is identified as a novel amplifier of the proto-oncogene c-MYC, a critical cancer driver that correlates with inferior clinical outcomes in the c- MYC-dependent cancer multiple myeloma, and overexpression of OTUB1 accelerates the growth of myel cancer cells. 3 PDF hop on the train gifWebSurprisingly, we found that OTUB1 suppresses RNF168-dependent poly-ubiquitination independently of its catalytic activity. OTUB1 does so by binding to and inhibiting UBC13 (also known as UBE2N), the cognate E2 enzyme for RNF168. This unusual mode of regulation is unlikely to be limited to UBC13 because analysis of OTUB1-associated … longwood gardens apartments rockford ilWebAug 4, 2024 · Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield Authors: Wang Shuansuo Chinese Academy... longwood gardens acreage