WebRK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3 … WebJun 1, 2024 · Inhibition of SARS-CoV-2 infection by RK-33 and C–4B in Vero E6 cells. A) Chemical structures of DDX3X inhibitors. B-D) Vero E6 cells were infected with SARS-CoV-2 at MOI 0.001 and, at the end of the adsorption period, were treated with RK-33 10 μM, C–4B 10 μM or left untreated, as indicated.
RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits …
WebJan 9, 2024 · These findings establish for the first time that RK-33 is a broad-spectrum antiviral agent that blocks DDX3X's catalytic activities in vitro and limits viral replication in … WebProduct Inquiry. RK-33 (1070773-09-9) is an inhibitor of the RNA helicase DDX3 – IC 50 ’s = 4.4-8.4 µM in high DDX3 expressing lung cancer cell lines A549, H1299, H23, and H460. … traduzione ekim
RK-33 CAS#1070773-09-9 MedKoo
WebJan 10, 2024 · The present study was carried out to develop cisplatin-loaded chitosan nanoparticles (CCNP) and cisplatin-loaded chitosan nanoparticle surface linked to rituximab (mAbCCNP) as targeted delivery ... WebNov 7, 2024 · DDX3X is an ATP-dependent RNA helicase that has recently attracted interest for its involvement in viral replication and oncogenic progression. Starting from hit compounds previously identified by our group, we have designed and synthesized a new series of DDX3X inhibitors that effectively blocked its helicase activity. These new … WebRK-33 is a DDX3 inhibitor. DDX3 has been identified as a RNA helicase that is overexpressed in various cancer types such as lung cancer and is correlated with lower survival in lung cancer patients. In vitro: RK-33 was reported to bind to DDX3 and abrogated its activity. Inhibition of DDX3 by RK-33 resulted in G1 cell cycle arrest, induced ... traduzione djadja aya nakamura